Human keratinocyte cultures in the investigation of early steps of human papillomavirus infection.


Human papillomaviruses (HPVs) are non-enveloped DNA viruses that are highly tropic for mucosal and cutaneous epithelia. The HPV life cycle is tightly linked to epithelial cell differentiation, where HPVs only infect the basal proliferating keratinocytes, and progeny virus assembly and release only occurs in differentiated upper-layer keratinocytes… (More)
DOI: 10.1007/7651_2013_49


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