Human kallikrein 2 (KLK2) promotes prostate cancer cell growth via function as a modulator to promote the ARA70-enhanced androgen receptor transactivation

@article{Shang2013HumanK2,
  title={Human kallikrein 2 (KLK2) promotes prostate cancer cell growth via function as a modulator to promote the ARA70-enhanced androgen receptor transactivation},
  author={Zhiqun Shang and Yuanjie Niu and Qiliang Cai and Jing Chen and Jianrong Tian and Shuyuan Yeh and Kuo-Pao Lai and Chawnshang Chang},
  journal={Tumor Biology},
  year={2013},
  volume={35},
  pages={1881-1890}
}
Recent data suggested that tissue human kallikrein 2 (KLK2) might be involved in the carcinogenesis and tumor metastasis of prostate cancer (PCa). However, the detailed pathophysiological roles of KLK2 in PCa remain unclear. We report here that KLK2 may be treated as a potential therapeutic target in castration-resistant PCa (CRPC). Histologic analyses show that the increased KLK2 expression is correlated with higher cell proliferation rate and lower cell apoptosis index in CRPC specimens… CONTINUE READING

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