Human junction adhesion molecule regulates tight junction resealing in epithelia.

  title={Human junction adhesion molecule regulates tight junction resealing in epithelia.},
  author={Yuan Liu and Asma Nusrat and Frederick J. Schnell and Titus A. Reaves and Sinead E Walsh and Mildred M Pochet and Charles A Parkos},
  journal={Journal of cell science},
  volume={113 ( Pt 13)},
Epithelial cells form a highly selective barrier and line many organs. The epithelial barrier is maintained by closely apposed cell-cell contacts containing tight junctions, the regulation of which is incompletely understood. Here we report the cloning, tissue localization and evidence for a role in epithelial barrier regulation of an immunoglobulin superfamily member that likely represents the human homolog of murine junction adhesion molecule (JAM). Analysis of the primary structure of human… CONTINUE READING
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