Human intrahepatic biliary epithelial cells proliferate in vitro in response to human hepatocyte growth factor.

@article{Joplin1992HumanIB,
  title={Human intrahepatic biliary epithelial cells proliferate in vitro in response to human hepatocyte growth factor.},
  author={Ruth Elizabeth Joplin and Takashi Hishida and Hirohito Tsubouchi and Yasushi Daikuhara and Reuben Ayres and James Max Neuberger and Alastair J. Strain},
  journal={The Journal of clinical investigation},
  year={1992},
  volume={90 4},
  pages={1284-9}
}
In previous studies, intrahepatic human biliary epithelial cells (BEC) were isolated in high purity. However, these cells demonstrated only limited growth responses. Here we report that human BEC proliferate in response to human hepatocyte growth factor (hHGF), retain BEC-specific phenotype, and can be serially passaged. BEC showed dose-dependent growth in response to 0.01-100 ng/ml hHGF. The maximum S-phase labeling index reached 40% with half-maximal stimulation at 1 ng/ml. The response of… CONTINUE READING

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