Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

  title={Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation},
  author={Xianqin Zhang and Dusan Bogunovic and B{\'e}atrice Payelle-Brogard and V{\'e}ronique François-Newton and Scott D Speer and Chao Yuan and Stefano Volpi and Zhi Li and Ozden Sanal and Davood Mansouri and I. Tezcan and Gillian I Rice and Chunyuan Chen and Nahal Mansouri and Seyed Alireza Mahdaviani and Yuval Itan and Bertrand Boisson and Satoshi Okada and Lu Zeng and Xing Wang and Hui Jiang and Wenqiang Liu and Tiantian Han and Delin Liu and Tao Ma and Bo Wang and Mugen Liu and Jing-Yu Liu and Qing Kenneth Wang and Dilek Yalnizoğlu and Lilliana Radoshevich and Gilles Uz{\'e} and Philippe Gros and Flore Rozenberg and S Zhang and Emmanuelle Jouanguy and Jacinta Bustamante and Adolfo Garc{\'i}a-Sastre and Laurent Abel and Pierre Lebon and Luigi D Notarangelo and Yanick J Crow and St{\'e}phanie Boisson-Dupuis and Jean-Laurent Casanova and Sandra Pellegrini},
Intracellular ISG15 is an interferon (IFN)-α/β-inducible ubiquitin-like modifier which can covalently bind other proteins in a process called ISGylation; it is an effector of IFN-α/β-dependent antiviral immunity in mice. We previously published a study describing humans with inherited ISG15 deficiency but without unusually severe viral diseases. We showed that these patients were prone to mycobacterial disease and that human ISG15 was non-redundant as an extracellular IFN-γ-inducing molecule… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
81 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 81 extracted citations

Similar Papers

Loading similar papers…