Human intestinal phenol sulfotransferase: assay conditions, activity levels and partial purification of the thermolabile form.

@article{Sundaram1989HumanIP,
  title={Human intestinal phenol sulfotransferase: assay conditions, activity levels and partial purification of the thermolabile form.},
  author={R. Shanmuga Sundaram and Carol L Szumlanski and Diane M. Otterness and Jeanne van Loon and Richard M. Weinshilboum},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1989},
  volume={17 3},
  pages={255-64}
}
Phenol sulfotransferase (PST) catalyzes the sulfate conjugation of catecholamines and phenolic and catechol drugs. The small intestine is an important drug-metabolizing organ. Other human tissues including brain, liver, and platelet contain at least two forms of PST. A thermolabile (TL) form catalyzes the sulfate conjugation of dopamine and other monoamines whereas a thermostable (TS) form of the enzyme catalyzes the sulfate conjugation of "simple" phenols such as p-nitrophenol. In this study… CONTINUE READING