Human intestinal mast cells are capable of producing different cytokine profiles: role of IgE receptor cross-linking and IL-4.

@article{Lorentz2000HumanIM,
  title={Human intestinal mast cells are capable of producing different cytokine profiles: role of IgE receptor cross-linking and IL-4.},
  author={Axel Lorentz and Silke Schwengberg and Gernot Sellge and Michael P Manns and Stephan C. Bischoff},
  journal={Journal of immunology},
  year={2000},
  volume={164 1},
  pages={
          43-8
        }
}
Mast cells are recognized as a new type of immunoregulatory cells capable of producing different cytokines. So far, little is known about the cytokine profile of mature human mast cells isolated from intestinal tissue and cultured in the presence of stem cell factor (SCF). We observed that these cells express the proinflammatory cytokines TNF-alpha, IL-1 beta, IL-6, IL-8, IL-16, and IL-18 without further stimulation. Both IgE-dependent and IgE-independent agonists (e.g., Gram-negative bacteria… CONTINUE READING

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