Human interleukin 4.

  title={Human interleukin 4.},
  author={Jacques Banchereau and Francine Bri{\`e}re and Jean Pierre Galizzi and Philippe Miossec and Françoise Rousset},
  journal={Journal of lipid mediators and cell signalling},
  volume={9 1},
Human IL-4 is a mature glycoprotein of 129 amino acids, mostly secreted by activated T cells. It is a pleiotropic cytokine which acts on T and B lymphocytes, monocytes, polymorphonuclears, fibroblasts and endothelial cells. In addition, it acts at various stages of cell differentiation, and its effects are also dependent on the cytokine environment. In particular, IL-4 blocks some of the effects of IL-2 whereas interferon-gamma blocks some of the effects of IL-4. In vitro and in vivo… CONTINUE READING


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