Human interferon-inducible protein 10: expression and purification of recombinant protein demonstrate inhibition of early human hematopoietic progenitors

@article{Sarris1993HumanIP,
  title={Human interferon-inducible protein 10: expression and purification of recombinant protein demonstrate inhibition of early human hematopoietic progenitors},
  author={Andreas H. Sarris and Hal E. Broxmeyer and Urs Wirthmueller and Nicos Karasavvas and Scott Cooper and Lan Lu and Jana Kr{\"u}ger and Jeffrey V Ravetch},
  journal={The Journal of Experimental Medicine},
  year={1993},
  volume={178},
  pages={1127 - 1132}
}
Human interferon-inducible protein 10 (IP-10), a member of the family of the small secreted proteins called intercrine cytokines or chemokines, is secreted by interferon gamma-stimulated T cells, monocytes, endothelial cells, and keratinocytes. We have begun to explore the biological properties of IP-10 by cloning and overexpression in baculovirus and in bacterial protein expression systems. A 9.9-kD protein was secreted by infected insect cells, which on sodium dodecyl sulfate-polyacrilamide… CONTINUE READING

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IP-10, a y-interferon-inducible protein related to interleukin-8, lacks neutrophil activating properties, lmmunol

  • B. Dewald, B. Moser, L. BarreUa, C. Schumacher, M. Baggiolini, I. Clark-Lewis
  • Lett. 32:81
  • 1992
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