Human insulinlike growth factor 1 gene transfer into paralyzed rat larynx: single vs multiple injection.

@article{Shiotani1999HumanIG,
  title={Human insulinlike growth factor 1 gene transfer into paralyzed rat larynx: single vs multiple injection.},
  author={Akihiro Shiotani and Bert W. O'malley and Michael E. Coleman and Paul Warren Flint},
  journal={Archives of otolaryngology--head & neck surgery},
  year={1999},
  volume={125 5},
  pages={555-60}
}
OBJECTIVE To compare the biological effects of single vs multiple treatment of rat denervated laryngeal muscle with human insulinlike growth factor 1 (hIGF1) gene therapy. EXPERIMENTAL METHODS OR DESIGN: A muscle-specific nonviral vector containing the alpha-actin promoter and hIGF1 gene formulated with polyvinyl polymers was injected into denervated adult rat thyroarytenoid muscle. The effects on animals given a single injection (n = 16) vs those given multiple injections (n = 14) vs control… CONTINUE READING