Human insulin. A review of its biological activity, pharmacokinetics and therapeutic use.

@article{Brogden1987HumanIA,
  title={Human insulin. A review of its biological activity, pharmacokinetics and therapeutic use.},
  author={Rex N. Brogden and R. C. Heel},
  journal={Drugs},
  year={1987},
  volume={34 3},
  pages={350-71}
}
Human insulin, whether produced by recombinant DNA techniques (biosynthetic, insulin crb) or enzymatic modification of porcine insulin (semisynthetic, insulin emp) is equivalent in biological activity to porcine insulin following intravenous administration. Slight differences between human and porcine insulin in hypoglycaemic activity after subcutaneous injection appear to be related to differences in absorption, and are unlikely to be of major clinical importance. Similarly, reported minor… CONTINUE READING