Human insulin receptor substrate-1: variant sequences in familial non-insulin-dependent diabetes mellitus.

@article{Armstrong1996HumanIR,
  title={Human insulin receptor substrate-1: variant sequences in familial non-insulin-dependent diabetes mellitus.},
  author={Matthew Armstrong and F. Duncan M. Haldane and Robert W Taylor and D. B. Humphriss and T. S. Berrish and Murray W. Stewart and Douglass Matthew Turnbull and Kurt George M M Alberti and Mark J Walker},
  journal={Diabetic medicine : a journal of the British Diabetic Association},
  year={1996},
  volume={13 2},
  pages={133-8}
}
The aetiology of NIDDM is uncertain, although family and twin studies indicate an important role for genetic factors in disease onset. The function and position of IRS-1 within the insulin signalling pathway make it a prime candidate gene for the development of insulin resistance and NIDDM. Insulin resistant families were identified by studying unaffected first degree relatives from families with 2 or more living NIDDM subjects. Insulin sensitivity was determined in the relatives using the… CONTINUE READING