Human insulin-induced lipoatrophy: a successful treatment with glucocorticoid.

@article{Ramos2006HumanIL,
  title={Human insulin-induced lipoatrophy: a successful treatment with glucocorticoid.},
  author={Alberto Jos{\'e} Santos Ramos and Marcella Alves de Farias},
  journal={Diabetes care},
  year={2006},
  volume={29 4},
  pages={
          926-7
        }
}
B efore the development of purified insulin in the 1970s, lipoatrophy was a common complication of insulin therapy (1,2). With the arrival of human insulin, lipoatrophy has decreased dramatically, becoming a rare problem in clinical practice. Lipoatrophies are considered an adverse immunological side effect of insulin therapy, and in some cases they are mediated by a local high production of tumor necrosis factor, which leads to a dedifferentiation of adipocytes in the subcutaneous tissue. The… CONTINUE READING

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