Human innate lymphoid cells.

@article{Hazenberg2014HumanIL,
  title={Human innate lymphoid cells.},
  author={Mette D. Hazenberg and Hergen Spits},
  journal={Blood},
  year={2014},
  volume={124 5},
  pages={
          700-9
        }
}
Innate lymphoid cells (ILCs) are lymphoid cells that do not express rearranged receptors and have important effector and regulatory functions in innate immunity and tissue remodeling. ILCs are categorized into 3 groups based on their distinct patterns of cytokine production and the requirement of particular transcription factors for their development and function. Group 1 ILCs (ILC1s) produce interferon γ and depend on Tbet, group 2 ILCs (ILC2s) produce type 2 cytokines like interleukin-5 (IL-5… 
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Human innate lymphoid cells.
IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity
TLDR
It is demonstrated that IL-1β was a critical activator of ILC2 cells, inducing proliferation and cytokine production and regulating the expression of epithelial cytokine receptors.
Innate Lymphoid Cells: The Innate Counterpart to T Helper Cells.
TLDR
This chapter introduces each subset of ILC (type 1-3) and the non-CRS pathologies they have been associated with in both mouse and human models and discusses the current research into ILCs in CRS, particularly ILC2s and NK cells in C RSwNP.
Development of Group 2 Innate Lymphoid Cells
Innate Lymphoid Cells in Graft‐Versus‐Host Disease
  • V. Kónya, J. Mjösberg
  • Biology, Medicine
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2015
TLDR
The current view of the immunological functions of human noncytotoxic ILC subsets is summarized and the potentially beneficial features of IL‐22 producing ILC3 in improving allo‐HCT efficacy by attenuating susceptibility to GVHD are discussed.
Differential Modulation of Human Innate Lymphoid Cell (ILC) Subsets by IL-10 and TGF-β
TLDR
Ex vivo activated ILC1 and ILC2 subsets were found to be a source of the immunoregulatory cytokine IL-10, raising the potential for ILC-mediated regulation of immune cells.
Plasticity of innate lymphoid cell subsets
TLDR
The ability of ILCs to communicate with the surrounding microenvironment is highlighted and the possible consequences of I LC plasticity are discussed, which improve understanding of the biological roles of these cells and offer promise for new strategies to treat inflammatory diseases and cancer.
Multidimensional molecular controls defining NK/ILC1 identity in cancers.
Non-cytotoxic Cardiac Innate Lymphoid Cells Are a Resident and Quiescent Type 2-Commited Population
TLDR
It is demonstrated that the heart, unlike other organs such as lung, cannot be infiltrated by circulating ILCs in adulthood even during cardiac inflammation or ischemia, and the ILC2s present during inflammatory conditions are derived from the heart-resident and quiescent steady-state population.
Fingolimod Alters Tissue Distribution and Cytokine Production of Human and Murine Innate Lymphoid Cells
TLDR
It is shown that human ILCs express S1PR1 mRNA and protein and migrate toward S1P receptor ligands in vivo and ex vivo, and provides insight into the impact of long term fingolimod use on ILC populations.
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References

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TLDR
The frequency of the ILC1 subset was much higher in inflamed intestine of people with Crohn's disease, which indicated a role for these IFN-γ-producing I LC1 cells in the pathogenesis of gut mucosal inflammation.
Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161
TLDR
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The transcription factor GATA3 is critical for the development of all IL-7Rα-expressing innate lymphoid cells.
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TLDR
The distinct localization and cellular expression of IL-4 and IL-13 explains their unique roles during allergic immunity.
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TLDR
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TLDR
It is shown that bacteria-driven innate colitis is associated with an increased production of IL-17 and interferon-γ in the colon, and IL-23-responsive innate intestinal cells are identified, which may represent a target in inflammatory bowel disease.
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