Human influenza virus NS1 protein enhances viral pathogenicity and acts as an RNA silencing suppressor in plants.

@article{Delgadillo2004HumanIV,
  title={Human influenza virus NS1 protein enhances viral pathogenicity and acts as an RNA silencing suppressor in plants.},
  author={Ma Otilia Delgadillo and Pilar S{\'a}enz and Beatriz Salvador and Juan Antonio Garc{\'i}a and Carmen Sim{\'o}n-Mateo},
  journal={The Journal of general virology},
  year={2004},
  volume={85 Pt 4},
  pages={993-9}
}
RNA silencing has a well-established function as an antiviral defence mechanism in plants and insects. Using an Agrobacterium-mediated transient assay, we report here that NS1 protein from human influenza A virus suppresses RNA silencing in plants in a manner similar to P1/HC-Pro protein of Tobacco etch potyvirus, a well-characterized plant virus silencing suppressor. Moreover, we have shown that NS1 protein expression strongly enhances the symptoms of Potato virus X in three different plant… CONTINUE READING