Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell-like metabolic reprogramming.

@article{Prigione2011HumanIP,
  title={Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell-like metabolic reprogramming.},
  author={Alessandro Prigione and Bjoern Lichtner and Heiner Kuhl and Eduard Alexander Struys and Mirjam M. C. Wamelink and Hans Lehrach and Markus Ralser and Bernd Timmermann and James Adjaye},
  journal={Stem cells},
  year={2011},
  volume={29 9},
  pages={1338-48}
}
Human induced pluripotent stem cells (iPSCs) have been recently found to harbor genomic alterations. However, the integrity of mitochondrial DNA (mtDNA) within reprogrammed cells has yet to be investigated. mtDNA mutations occur at a high rate and contribute to the pathology of a number of human disorders. Furthermore, the lack of mtDNA integrity may alter cellular bioenergetics and limit efficient differentiation. We demonstrated previously that the derivation of iPSCs is associated with… CONTINUE READING
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