Human induced pluripotent stem cells can reach complete terminal maturation: in vivo and in vitro evidence in the erythropoietic differentiation model

@article{Kobari2012HumanIP,
  title={Human induced pluripotent stem cells can reach complete terminal maturation: in vivo and in vitro evidence in the erythropoietic differentiation model},
  author={Ladan Kobari and Frank Yates and Noufissa Oudrhiri and Alain Francina and Laurent Kiger and Christelle Mazurier and Shaghayegh Rouzbeh and Wassim El-Nemer and Natasha H{\'e}bert and Marie-Catherine Giarratana and Sabine François and Alain Chapel and H{\'e}l{\`e}ne Lapillonne and Dominique Luton and Annelise Bennaceur-Griscelli and Luc Douay},
  journal={Haematologica},
  year={2012},
  volume={97},
  pages={1795 - 1803}
}
  • Ladan Kobari, Frank Yates, +13 authors Luc Douay
  • Published 2012
  • Biology, Medicine
  • Haematologica
  • Background Human induced pluripotent stem cells offer perspectives for cell therapy and research models for diseases. We applied this approach to the normal and pathological erythroid differentiation model by establishing induced pluripotent stem cells from normal and homozygous sickle cell disease donors. Design and Methods We addressed the question as to whether these cells can reach complete erythroid terminal maturation notably with a complete switch from fetal to adult hemoglobin. Sickle… CONTINUE READING

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    Human induced pluripotent stem cell derived erythroblasts can undergo definitive erythropoiesis and co-express gamma and beta globins

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