Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway

Abstract

Human inactive X chromosome (Xi) forms a compact structure called the Barr body, which is enriched in repressive histone modifications such as trimethylation of histone H3 Lys9 (H3K9me3) and Lys27 (H3K27me3). These two histone marks are distributed in distinct domains, and X-inactive specific transcript (XIST) preferentially colocalizes with H3K27me3… (More)
DOI: 10.1038/nsmb.2532

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@article{Nozawa2013HumanIX, title={Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway}, author={Ryu-suke Nozawa and Koji Nagao and Ken-Taro Igami and Sachiko Shibata and Natsuko Shirai and Naohito Nozaki and Takashi Sado and Hiroshi Kimura and Chikashi Obuse}, journal={Nature Structural &Molecular Biology}, year={2013}, volume={20}, pages={566-573} }