Human in vivo comparative study of zinc and copper transmetallation after administration of magnetic resonance imaging contrast agents.

@article{Puttagunta1996HumanIV,
  title={Human in vivo comparative study of zinc and copper transmetallation after administration of magnetic resonance imaging contrast agents.},
  author={N R Puttagunta and Wendell A Gibby and Gary T. Smith},
  journal={Investigative radiology},
  year={1996},
  volume={31 12},
  pages={739-42}
}
RATIONALE AND OBJECTIVES The authors compare in vivo transmetallation of three magnetic resonance contrast agents in humans in terms of their kinetic stability. METHODS Blood and urine samples were taken before and after the intravenous injection of gadolinium (Gd)-HP-DO3A, Gd-DTPA, or Gd-DTPA-BMA at 0.1 mmol/kg to healthy volunteers. Serum and urine were assayed for zinc, copper, and Gd, using inductively coupled plasma atomic emission spectrometer. RESULTS Gadolinium-DTPA-BMA caused the… CONTINUE READING

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