Human in Vivo Pharmacokinetics of [14C]Dibenzo[def,p]chrysene by Accelerator Mass Spectrometry Following Oral Microdosing

@inproceedings{Madeen2015HumanIV,
  title={Human in Vivo Pharmacokinetics of
[14C]Dibenzo[def,p]chrysene by Accelerator
Mass Spectrometry Following Oral Microdosing},
  author={Erin P Madeen and Richard A. Corley and Susan Ritger Crowell and Kenneth W. Turteltaub and Ted J. Ognibene and Mike Malfatti and Tammie J. McQuistan and Mary Garrard and Dan Sudakin and David Edward Williams},
  booktitle={Chemical research in toxicology},
  year={2015}
}
Dibenzo(def,p)chrysene (DBC), (also known as dibenzo[a,l]pyrene), is a high molecular weight polycyclic aromatic hydrocarbon (PAH) found in the environment, including food, produced by the incomplete combustion of hydrocarbons. DBC, classified by IARC as a 2A probable human carcinogen, has a relative potency factor (RPF) in animal cancer models 30-fold higher than benzo[a]pyrene. No data are available describing the disposition of high molecular weight (>4 rings) PAHs in humans to compare to… CONTINUE READING