Human immunoglobulin selection associated with class switch and possible tolerogenic origins for C delta class-switched B cells.

@article{Zheng2004HumanIS,
  title={Human immunoglobulin selection associated with class switch and possible tolerogenic origins for C delta class-switched B cells.},
  author={Nai-Ying Zheng and Kenneth H. Wilson and Xiaojian Wang and Angela Boston and Grant R. Kolar and Stephen M. Jackson and Yong-Jun Liu and Virginia Pascual and J. Donald Capra and Patrick C. Wilson},
  journal={The Journal of clinical investigation},
  year={2004},
  volume={113 8},
  pages={1188-201}
}
Current paradigms of peripheral B cell selection suggest that autoreactive B cells are controlled by clonal deletion, anergy, and developmental arrest. We report that changes to the human antibody repertoire likely resulting from these mechanisms both for a well-characterized autoreactivity from antibodies encoded by the V(H)4-34 gene and for other hallmarks of an autoreactive repertoire are apparent mainly for class-switched B cells and not for IgM germinal center, IgM memory, or IgM plasma… CONTINUE READING
47 Citations
55 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 47 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 55 references

Similar Papers

Loading similar papers…