Human immunoglobulin preparations for intravenous use prevent experimental autoimmune uveoretinitis.

@article{Saoudi1993HumanIP,
  title={Human immunoglobulin preparations for intravenous use prevent experimental autoimmune uveoretinitis.},
  author={Abdelhadi Saoudi and V Hurez and Yvonne de Kozak and Joelle Kuhn and Srini V Kaveri and Michel Daniel Kazatchkine and Philippe Druet and Blanche Bellon},
  journal={International immunology},
  year={1993},
  volume={5 12},
  pages={1559-67}
}
We have evaluated the effect of human Igs for intravenous use (IVIg) on the onset and development of experimental autoimmune uveoretinitis (EAU), a T cell-dependent autoimmune disease induced in rats by a single immunization with retinal S-antigen (S-Ag). Five consecutive daily infusions of IVIg, starting on the same day as S-Ag immunization, protected (Lewis x Brown-Norway) F1 rats against EAU. The prevention of EAU was IVIg-specific, i.e. mediated by pooled human IgG from multiple donors… CONTINUE READING
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