Human immunoglobulin G subclass immune response to outer membrane antigens in meningococcal group B vaccine.

@article{Wedege1987HumanIG,
  title={Human immunoglobulin G subclass immune response to outer membrane antigens in meningococcal group B vaccine.},
  author={Elisabeth Wedege and T E Michaelsen},
  journal={Journal of clinical microbiology},
  year={1987},
  volume={25 8},
  pages={1349-53}
}
The immunoglobulin G (IgG) subclass distribution of antibodies against the major outer membrane proteins from serotype 2a Neisseria meningitidis in human vaccinees was studied by immunoblotting. The volunteers received two doses of a noncovalent complex of group B polysaccharide and outer membrane material from the same meningococcal strain. Six weeks after the first vaccination the antibodies mounted against the class 1 and 5 proteins belonged mainly to the IgG1 and IgG3 subclasses. However… CONTINUE READING