Human immunodeficiency virus type 1 viral protein R localization in infected cells and virions.

@article{Lu1993HumanIV,
  title={Human immunodeficiency virus type 1 viral protein R localization in infected cells and virions.},
  author={Yi Lung Lu and Paul Spearman and L. S. Ratner},
  journal={Journal of virology},
  year={1993},
  volume={67 11},
  pages={6542-50}
}
The subcellular localization of human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) was examined by subcellular fractionation. In HIV-1-infected peripheral blood mononuclear cells, Vpr was found in the nuclear and membrane fractions as well as the conditioned medium. Expression of Vpr without other HIV-1 proteins, in two different eukaryotic expression systems, demonstrated a predominant localization of Vpr in the nuclear matrix and chromatin extract fractions. Deletion of the… CONTINUE READING

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