Human immunodeficiency virus type 1 reverse transcriptase: enhancement of activity by interaction with cellular topoisomerase I.

@article{Takahashi1995HumanIV,
  title={Human immunodeficiency virus type 1 reverse transcriptase: enhancement of activity by interaction with cellular topoisomerase I.},
  author={Hiroyuki Takahashi and Masafumi Matsuda and Asato Kojima and Tetsutaro Sata and Toshiwo Andoh and Takeshi Kurata and Kunio Nagashima and William Walmsley Hall},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 12},
  pages={
          5694-8
        }
}
A number of studies have suggested that topoisomerase I (topo I) activity may be important in human immunodeficiency virus type 1 (HIV-1) replication. Specifically it has been reported that purified virus particles have topo I activity and that inhibitors of this enzyme can inhibit virus replication in vitro. We have investigated a possible association of HIV-1 gag proteins with topo I activity. We found that whereas the gag-encoded proteins by themselves do not have activity, the nucleocapsid… CONTINUE READING
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