Human immunodeficiency virus type 1 replication is blocked prior to reverse transcription and integration in freshly isolated peripheral blood monocytes.

@article{Sonza1996HumanIV,
  title={Human immunodeficiency virus type 1 replication is blocked prior to reverse transcription and integration in freshly isolated peripheral blood monocytes.},
  author={Secondo Sonza and Anne L. Maerz and Nicholas J. Deacon and Jayesh Meanger and John Mills and Suzanne M. Crowe},
  journal={Journal of virology},
  year={1996},
  volume={70 6},
  pages={3863-9}
}
Peripheral blood monocytes are resistant to productive human immunodeficiency virus type 1 (HIV-1) infection in vitro immediately after isolation. No viral cDNA (either early or late transcripts) was detected by PCR in monocytes exposed to virus on the day of isolation. In contrast, in monocytes cultured for as little as 1 day, initiated and completed reverse transcripts were readily detectable within 24 h of infection with both HIV-1(Ba-L) and primary isolates. The levels of initiated… CONTINUE READING

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