Human immunodeficiency virus type 1 replication and regulation of APOBEC3G by peptidyl prolyl isomerase Pin1.

@article{Watashi2008HumanIV,
  title={Human immunodeficiency virus type 1 replication and regulation of APOBEC3G by peptidyl prolyl isomerase Pin1.},
  author={Koichi Watashi and Mohammad Naseem Khan and Venkat S. R. K. Yedavalli and Man Lung Yeung and Klaus Strebel and K T Jeang},
  journal={Journal of virology},
  year={2008},
  volume={82 20},
  pages={9928-36}
}
APOBEC3G (A3G) is a cytidine deaminase that restricts human immunodeficiency virus type 1 (HIV-1) replication. HIV-1 synthesizes a viral infectivity factor (Vif) to counter A3G restriction. Currently, it is poorly understood how A3G expression/activity is regulated by cellular factors. Here, we show that the prolyl isomerase Pin1 protein modulates A3G expression. Pin1 was found to be an A3G-interacting protein that reduces A3G expression and its incorporation into HIV-1 virion, thereby limiting… CONTINUE READING