Human immunodeficiency virus type 1 protease inhibitors.

  title={Human immunodeficiency virus type 1 protease inhibitors.},
  author={Cheryl Mcdonald and Daniel R. Kuritzkes},
  journal={Archives of internal medicine},
  volume={157 9},
Until recently, treatment for human immunodeficiency virus type 1 (HIV-1) infection was limited to the use of nucleoside inhibitors of the viral enzyme reverse transcriptase. While these agents initially offered promise, they have only modest antiviral activity and the benefits of treatment are limited by the emergence of drug resistance and dose-limiting toxic effects. Development of more potent drugs that target different stages of the virus life cycle has thus been aggressively pursued… CONTINUE READING