Human immunodeficiency virus type 1 particles pseudotyped with envelope proteins that fuse at low pH no longer require Nef for optimal infectivity.

@article{Chazal2001HumanIV,
  title={Human immunodeficiency virus type 1 particles pseudotyped with envelope proteins that fuse at low pH no longer require Nef for optimal infectivity.},
  author={Nathalie Chazal and Gerry Singer and Christopher Aiken and M L Hammarskj{\"o}ld and David Rekosh},
  journal={Journal of virology},
  year={2001},
  volume={75 8},
  pages={4014-8}
}
We have investigated the effects of Nef on infectivity in the context of various viral envelope proteins. These experiments were performed with a minimal vector system where Nef is the only accessory protein present. Our results support the hypothesis that the route of entry influences the ability of Nef to enhance human immunodeficiency virus (HIV) infectivity. We show that HIV particles pseudotyped with Ebola virus glycoprotein or vesicular stomatitis virus glycoprotein (VSV-G), which fuse at… CONTINUE READING