Human immunodeficiency virus type 1 molecular evolution and the measure of selection.

@article{Rodrigo1996HumanIV,
  title={Human immunodeficiency virus type 1 molecular evolution and the measure of selection.},
  author={Allen G. Rodrigo and James I. Mullins},
  journal={AIDS research and human retroviruses},
  year={1996},
  volume={12 18},
  pages={
          1681-5
        }
}
Human immunodeficiency virus (HIV) envelope genes are highly variable between and often within individuals. Part of this variability is thought to be the result of immune-mediated positive selection for sequence diversity. To measure positive selection it has become customary in HIV research to calculate the ratio of the proportions of synonymous (ds) and nonsynonymous (dn) substitutions per potential synonymous or nonsynonymous site, respectively. However, another measure that can be used is… CONTINUE READING
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