Human immunodeficiency virus type 1 is trapped by acidic but not by neutralized human cervicovaginal mucus.

@article{Lai2009HumanIV,
  title={Human immunodeficiency virus type 1 is trapped by acidic but not by neutralized human cervicovaginal mucus.},
  author={Samuel K Lai and Kaoru Hida and Shetha A. Shukair and Yingying Wang and Anna Regina Corbo Luiz Henrique de Figueiredo and Richard Cone and Thomas J Hope and Justin Hanes},
  journal={Journal of virology},
  year={2009},
  volume={83 21},
  pages={11196-200}
}
To reliably infect a primate model for human immunodeficiency virus (HIV), approximately 10,000-fold more virus must be delivered vaginally than intravenously. However, the vaginal mechanisms that help protect against HIV are poorly understood. Here, we report that human cervicovaginal mucus (CVM), obtained from donors with normal lactobacillus-dominated vaginal flora, efficiently traps HIV, causing it to diffuse more than 1,000-fold more slowly than it does in water. Lactobacilli acidify CVM… CONTINUE READING
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