Human immunodeficiency virus type 1 integrase protein promotes reverse transcription through specific interactions with the nucleoprotein reverse transcription complex.

@article{Wu1999HumanIV,
  title={Human immunodeficiency virus type 1 integrase protein promotes reverse transcription through specific interactions with the nucleoprotein reverse transcription complex.},
  author={Xue-ling Wu and Honglei Liu and Haixia Xiao and Joan A Conway and E M Hehl and Ganjam V. Kalpana and Vivek Prasad and John C Kappes},
  journal={Journal of virology},
  year={1999},
  volume={73 3},
  pages={2126-35}
}
The human immunodeficiency virus type 1 (HIV-1) integrase protein (IN) is essential for integration of the viral DNA into host cell chromosomes. Since IN is expressed and assembled into virions as part of the 160-kDa Gag-Pol precursor polyprotein and catalyzes integration of the provirus in infected cells as a mature 32-kDa protein, mutations in IN are pleiotropic and may affect virus replication at different stages of the virus life cycle in addition to integration. Several different… CONTINUE READING
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