Human immunodeficiency virus type 1 incorporates both glycosyl phosphatidylinositol-anchored CD55 and CD59 and integral membrane CD46 at levels that protect from complement-mediated destruction.

@article{Saifuddin1997HumanIV,
  title={Human immunodeficiency virus type 1 incorporates both glycosyl phosphatidylinositol-anchored CD55 and CD59 and integral membrane CD46 at levels that protect from complement-mediated destruction.},
  author={Mohammed Syafiek Saifuddin and T Hedayati and John P Atkinson and Mark Holguin and Charles F. Parker and Gregory T. Spear},
  journal={The Journal of general virology},
  year={1997},
  volume={78 ( Pt 8)},
  pages={1907-11}
}
Human immunodeficiency virus type 1 (HIV-1) can be either resistant or sensitive to complement-mediated destruction depending on the host cells. Incorporation of different levels of host cell CD46, CD55 and CD59 may account for this differential sensitivity to complement. However, it has not been determined whether CD46, CD55 and CD59 can all be incorporated at levels which protect virions. To determine whether each of these proteins can protect HIV-1, virions were derived from CHO cells… CONTINUE READING
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Protectin ( CD 59 ) : complement lysis inhibitor and prototype domain in a new protein superfamily

  • S. Meri
  • Immunologist
  • 1994
1 Excerpt

Protectin (CD59) : complement lysis inhibitor and prototype domain in a new protein

  • S. Meri
  • superfamily. Immunologist
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2 Excerpts

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