Human immunodeficiency virus type 1 envelope glycoprotein is modified by O-linked oligosaccharides.

@article{Bernstein1994HumanIV,
  title={Human immunodeficiency virus type 1 envelope glycoprotein is modified by O-linked oligosaccharides.},
  author={Helene B. Bernstein and Simon P Tucker and Eric Hunter and John S. Schutzbach and Richard W. Compans},
  journal={Journal of virology},
  year={1994},
  volume={68 1},
  pages={463-8}
}
The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein has been shown to be extensively modified by N-linked glycosylation; however, the presence of O-linked carbohydrates on the glycoprotein has not been firmly established. We have found that enzymatic deglycosylation of the HIV-1 envelope glycoprotein with neuraminidase and O-glycosidase results in a decrease in the apparent molecular weight of the envelope glycoprotein. This result was observed in both vaccinia virus… CONTINUE READING
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