Human immunodeficiency virus type 1 cellular host range, replication, and cytopathicity are linked to the envelope region of the viral genome.

@article{YorkHiggins1990HumanIV,
  title={Human immunodeficiency virus type 1 cellular host range, replication, and cytopathicity are linked to the envelope region of the viral genome.},
  author={D York-Higgins and Cecilia Cheng-Mayer and David M Bauer and Jay A. Levy and Dino Dina},
  journal={Journal of virology},
  year={1990},
  volume={64 8},
  pages={4016-20}
}
Human immunodeficiency virus type 1 (HIV-1) isolates vary in their in vitro biologic characteristics such as cellular host range, replication kinetics, and cytopathicity. In this study, we molecularly exchanged equivalent regions between two cloned HIV-1 isolates with differing replicative and cytopathic properties. To facilitate generation of recombinant viruses, we used a method involving cotransfection of human monolayer cells with plasmid constructs containing half of the biologically… CONTINUE READING

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