Human immunodeficiency virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinases in human neurons.

@article{Lannuzel1997HumanIV,
  title={Human immunodeficiency virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinases in human neurons.},
  author={Annie Lannuzel and Jean Barnier and Christiane H{\'e}ry and Van Thanh Huynh and Beno{\^i}t Guibert and Françoise Gray and Jean Didier Vincent and Marc Tardieu},
  journal={Annals of neurology},
  year={1997},
  volume={42 6},
  pages={847-56}
}
Detection of apoptotic neurons and microglial cells in the brains of human immunodeficiency virus type 1 (HIV-1)-infected patients has suggested that programmed cell death may be implicated in the physiopathology of HIV-1 encephalopathy. To analyze in vitro the intracellular signals induced by HIV-1 in human neurons and the associated neuronal death, we tested cultured human central nervous system (CNS) cells for apoptosis induced by HIV-1 and gp120 and for signaling pathways activated by gp120… CONTINUE READING

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