Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4.

@article{Willey1992HumanIV,
  title={Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4.},
  author={Ronald L Willey and Frank M Maldarelli and Malcolm A Martin and Klaus Strebel},
  journal={Journal of virology},
  year={1992},
  volume={66 12},
  pages={7193-200}
}
CD4 is an integral membrane glycoprotein which is known as the human immunodeficiency virus (HIV) receptor for infection of human cells. The protein is synthesized in the endoplasmic reticulum (ER) and subsequently transported to the cell surface via the Golgi complex. HIV infection of CD4+ cells leads to downmodulation of cell surface CD4, due at least in part to the formation of stable intracellular complexes between CD4 and the HIV type 1 (HIV-1) Env precursor polyprotein gp160. This process… CONTINUE READING
Highly Influential
This paper has highly influenced 15 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 188 extracted citations

Vpu and BST2: Still Not There Yet?

Front. Microbio. • 2012
View 10 Excerpts
Highly Influenced

Mechanistic understanding of N-glycosylation in Ebola virus glycoprotein maturation and function.

The Journal of biological chemistry • 2017
View 5 Excerpts
Highly Influenced

Host restriction factors blocking retroviral replication.

Annual review of genetics • 2008
View 9 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…