Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4.

  title={Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4.},
  author={Ronald L Willey and Frank M Maldarelli and Malcolm A Martin and Klaus Strebel},
  journal={Journal of virology},
  volume={66 12},
CD4 is an integral membrane glycoprotein which is known as the human immunodeficiency virus (HIV) receptor for infection of human cells. The protein is synthesized in the endoplasmic reticulum (ER) and subsequently transported to the cell surface via the Golgi complex. HIV infection of CD4+ cells leads to downmodulation of cell surface CD4, due at least in part to the formation of stable intracellular complexes between CD4 and the HIV type 1 (HIV-1) Env precursor polyprotein gp160. This process… CONTINUE READING
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