Human immunodeficiency virus type 1 Vpr inhibits axonal outgrowth through induction of mitochondrial dysfunction.

@article{Kitayama2008HumanIV,
  title={Human immunodeficiency virus type 1 Vpr inhibits axonal outgrowth through induction of mitochondrial dysfunction.},
  author={Hiroko Kitayama and Yoshiharu Miura and Yoshinori Ando and Shigeki Hoshino and Yukihito Ishizaka and Yoshio Koyanagi},
  journal={Journal of virology},
  year={2008},
  volume={82 5},
  pages={
          2528-42
        }
}
Human immunodeficiency virus type 1 (HIV-1)-infected macrophages damage mature neurons in the brain, although their effect on neuronal development has not been clarified. In this study, we show that HIV-1-infected macrophages produce factors that impair the development of neuronal precursor cells and that soluble viral protein R (Vpr) is one of the factors that has the ability to suppress axonal growth. Cell biological analysis revealed that extracellularly administered recombinant Vpr (rVpr… CONTINUE READING

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