Human immunodeficiency virus type 1 Vpr polymorphisms associated with progressor and nonprogressor individuals alter Vpr-associated functions.

@article{Hadi2014HumanIV,
  title={Human immunodeficiency virus type 1 Vpr polymorphisms associated with progressor and nonprogressor individuals alter Vpr-associated functions.},
  author={Kevin Kusuma Hadi and Leah A. Walker and Debjani Guha and Ramachandran Murali and Simon C Watkins and Patrick M. Tarwater and Alagarsamy Srinivasan and Velpandi Ayyavoo},
  journal={The Journal of general virology},
  year={2014},
  volume={95 Pt 3},
  pages={
          700-11
        }
}
Following infection with Human immunodeficiency virus 1 (HIV-1) there is a remarkable variation in virus replication and disease progression. Both host and viral factors have been implicated in the observed differences in disease status. Here, we focus on understanding the contribution of HIV-1 viral protein R (Vpr) by evaluating the disease-associated Vpr polymorphism and its biological functions from HIV-1 positive rapid progressor (RP) and long-term nonprogressor (LTNP) subjects. Results… CONTINUE READING

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