Human immunodeficiency virus type 1 Vif inhibits packaging and antiviral activity of a degradation-resistant APOBEC3G variant.

@article{Opi2007HumanIV,
  title={Human immunodeficiency virus type 1 Vif inhibits packaging and antiviral activity of a degradation-resistant APOBEC3G variant.},
  author={Sandrine Opi and Sandra Kao and Ritu Goila-Gaur and Mohammad Ayub Khan and Eri Miyagi and Hiroaki Takeuchi and Klaus Strebel},
  journal={Journal of virology},
  year={2007},
  volume={81 15},
  pages={8236-46}
}
Human immunodeficiency virus type 1 (HIV-1) Vif counteracts the antiviral activity of the human cytidine deaminase APOBEC3G (APO3G) by inhibiting its incorporation into virions. This has been attributed to the Vif-induced degradation of APO3G by cytoplasmic proteasomes. We recently demonstrated that although APO3G has a natural tendency to form RNA-dependent homo-multimers, multimerization was not essential for encapsidation into HIV-1 virions or antiviral activity. We now demonstrate that a… CONTINUE READING
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