Human immunodeficiency virus type-1 Tat protein induces nuclear factor (NF)-kappaB activation and oxidative stress in microglial cultures by independent mechanisms.

@article{Nicolini2001HumanIV,
  title={Human immunodeficiency virus type-1 Tat protein induces nuclear factor (NF)-kappaB activation and oxidative stress in microglial cultures by independent mechanisms.},
  author={Alessia Nicolini and Maria Antonietta Ajmone-Cat and Antonietta Bernardo and Giulio Levi and Luisa Minghetti},
  journal={Journal of neurochemistry},
  year={2001},
  volume={79 3},
  pages={
          713-6
        }
}
We have extended our previous findings and shown that human immunodeficiency virus Tat protein, in addition to nitric oxide (NO), stimulated rat microglial cultures to release pro-inflammatory cytokine interleukin-1beta and tumour necrosis factor-alpha in a nuclear factor (NF)-kappaB-dependent manner. At the same time, Tat stimulated the accumulation of free radicals, as indicated by the increased levels of isoprostane 8-epi-prostaglandin F(2alpha) (8-epi-PGF(2alpha)), a reliable marker of… CONTINUE READING

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