Human immunodeficiency virus type 1 Tat prevents dephosphorylation of Sp1 by TCF-4 in astrocytes.

@article{Rossi2006HumanIV,
  title={Human immunodeficiency virus type 1 Tat prevents dephosphorylation of Sp1 by TCF-4 in astrocytes.},
  author={Andrea Rossi and Ruma Mukerjee and Pasquale Ferrante and Kamel Khalili and Shohreh Amini and Bassel E. Sawaya},
  journal={The Journal of general virology},
  year={2006},
  volume={87 Pt 6},
  pages={1613-23}
}
Previous examination of the effect of TCF-4 on transcription of the human immunodeficiency virus type 1 (HIV-1) promoter in human astrocytic cells found that TCF-4 affects the HIV-1 promoter through the GC-rich domain (nt -80 to nt -68). Here, the physical interaction and a functional consequence of TCF4-Sp1 contact were characterized. It was shown that expression of TCF-4 in U-87 MG (human astrocytic) cells decreased basal and Sp1-mediated transcription of the HIV-1 promoter. Results from a… CONTINUE READING