Human immunodeficiency virus type 1 Rev is required in vivo for binding of poly(A)-binding protein to Rev-dependent RNAs.

@article{Campbell1994HumanIV,
  title={Human immunodeficiency virus type 1 Rev is required in vivo for binding of poly(A)-binding protein to Rev-dependent RNAs.},
  author={Lia H. Campbell and Keith Thomas Borg and Julia Katherine Haines and Randall T. Moon and Daniel R Schoenberg and S J Arrigo},
  journal={Journal of virology},
  year={1994},
  volume={68 9},
  pages={5433-8}
}
In the absence of Rev or the Rev-responsive element, the Rev-dependent human immunodeficiency virus type 1 (HIV-1) RNAs do not behave as mRNAs; rather, they exhibit nuclear defects in splicing and/or nuclear export and cytoplasmic defects in stability and translation. A translational initiation factor, eIF-5A, has recently been shown to bind specifically to… CONTINUE READING