Human immunodeficiency virus type 1 (HIV-1) and human hematopoietic progenitor cells


Besides a progressive depletion of CD4+ T-lymphocytes, other peripheral blood cytopenias, (granulocytopenia, anemia and thrombocytopenia) are frequently observed in HIV-1 seropositive individuals, especially in patients with overt AIDS. Various experimental evidences suggest that HIV-1 could play a direct role in the pathogenesis of HIV-1 related peripheral blood cytopenias, affecting the survival/proliferation capacity of hematopoietic progenitors. CD34+ human hematopoietic progenitors, however, are substantially not susceptible to HIV-1 infection either in vitro and in vivo and their defects seem rather related to an alteration of bone marrow and peripheral blood microenvironments due to the presence of soluble HIV-1 specific products.

DOI: 10.1007/BF01311169

Cite this paper

@article{Re1994HumanIV, title={Human immunodeficiency virus type 1 (HIV-1) and human hematopoietic progenitor cells}, author={Maria Carla Re and Giuliano Furlini and Giorgio Zauli and Michele La Placa}, journal={Archives of Virology}, year={1994}, volume={137}, pages={1-23} }