Human immunodeficiency virus type 1 (HIV-1) tat induces nitric-oxide synthase in human astroglia.

@article{Liu2002HumanIV,
  title={Human immunodeficiency virus type 1 (HIV-1) tat induces nitric-oxide synthase in human astroglia.},
  author={Xiaojuan Liu and Malabendu Jana and Subhajit Dasgupta and Sreenivas Koka and Jun He and Charles James Wood and Kalipada Pahan},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 42},
  pages={
          39312-9
        }
}
Human immunodeficiency virus type 1 (HIV-1) infection is known to cause neuronal injury and dementia in a significant proportion of patients. However, the mechanism by which HIV-1 mediates its deleterious effects in the brain is poorly defined. The present study was undertaken to investigate the effect of the HIV-1 tat gene on the expression of inducible nitric-oxide synthase (iNOS) in human U373MG astroglial cells and primary astroglia. Expression of the tat gene as RSV-tat but not that of the… CONTINUE READING

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HIV-1 Tat Induces iNOS in Astroglia

L. I. Strelow, D. Janigro, J. A. Nelson
  • Adv. Virus Res
  • 2001
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