Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors.

@article{Rittinger1995HumanIV,
  title={Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors.},
  author={Katrin Rittinger and Gilles Divita and Roger S. Goody},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 17},
  pages={8046-9}
}
A combination of transient kinetic and equilibrium titration methods has been used to show that both primer/template and nucleotide binding to human immunodeficiency virus type 1 (HIV-1) reverse transcriptase are two-step processes. In both cases, after initial formation of relatively weakly bound states, isomerization reactions lead to tightly bound states… CONTINUE READING