Human immunodeficiency virus nef gene expression affects generation and function of human T cells, but not dendritic cells.

@article{Verhasselt1999HumanIV,
  title={Human immunodeficiency virus nef gene expression affects generation and function of human T cells, but not dendritic cells.},
  author={Bruno Verhasselt and Evelien Naessens and Chris Verhofstede and Magda De Smedt and S Schollen and Tessa Kerre and Dominique Vanhecke and Jean Plum},
  journal={Blood},
  year={1999},
  volume={94 8},
  pages={2809-18}
}
Human immunodeficiency virus (HIV)-infected individuals develop an acquired immune deficiency syndrome (AIDS) due to loss in their lymphocyte numbers and cellular defects in T cells and antigen-presenting cells (APC). HIV infection of the thymus results in deficient replenishment of the peripheral naive T-cell pool. The HIV nef gene was shown to be important for progression towards AIDS and cellular depletion of the infected thymus. Here, we demonstrate by retroviral gene transfer that nef… CONTINUE READING

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