Human immunodeficiency virus envelope V1 and V2 regions influence replication efficiency in macrophages by affecting virus spread.

@article{Toohey1995HumanIV,
  title={Human immunodeficiency virus envelope V1 and V2 regions influence replication efficiency in macrophages by affecting virus spread.},
  author={Kelleen Toohey and Kathy Wehrly and Jane Nishio and S M Perryman and Bruce Chesebro},
  journal={Virology},
  year={1995},
  volume={213 1},
  pages={70-9}
}
The V3 hypervariable region of the HIV-1 envelope protein is a major determinant of viral tropism for macrophages. However, the replication of macrophage-tropic HIV-1 strains varies considerably in macrophages, and this variability has been linked to the V1 and V2 envelope regions. In the present study, recombinant HIV clones were generated by inserting V1 and V2 sequences from the Ba-L HIV isolate, which has a high macrophage replication level, into the genomic background of a macrophage… CONTINUE READING

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