Human immunodeficiency virus and the central nervous system.

  title={Human immunodeficiency virus and the central nervous system.},
  author={Dorothy Spencer and Richard W. Price},
  journal={Annual review of microbiology},
Neurological disease frequently complicates HIV-1 infection. In addition to opportunistic infections, a syndrome of combined cognitive and motor impairment, referred to as the AIDS dementia complex, has been recognized. While presumed to relate to HIV-1 itself, the pathogenesis of this syndrome remains uncertain. Because of the limited extent of productive brain HIV-1 infection in many cases, and because such infection involves macrophages and microglia rather than cells of neuroectodermal… CONTINUE READING


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