Human immunodeficiency virus-1 disease progression in hemophiliacs.

  title={Human immunodeficiency virus-1 disease progression in hemophiliacs.},
  author={Paul R Becherer and M L Smiley and Thomas J. Matthews and Kent J. Weinhold and Campbell W Mcmillan and Gilbert C. White},
  journal={American journal of hematology},
  volume={34 3},
A retrospective study of 153 hemophiliacs infected with human immunodeficiency virus-1 (HIV-1) was performed to determine the clinical and immunological consequences of HIV-1 infection and the markers and cofactors associated with these changes. Nearly 80% of HIV-1-infected hemophiliacs have developed a significant reduction in their CD-4+ counts (less than 400 CD-4+ cells/mm3) with 40% having less than 200 CD-4+ cells/mm3 by the end of 1987. The rate of CD-4+ cell count decline was slightly… CONTINUE READING